Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer—Shifting the paradigm
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چکیده
منابع مشابه
Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer--shifting the paradigm.
Recent morphologic, immunohistochemical, and molecular genetic studies have led to the development of a new paradigm for the pathogenesis and origin of epithelial ovarian cancer based on a dualistic model of carcinogenesis that divides epithelial ovarian cancer into 2 broad categories designated types I and II. Type I tumors comprise low-grade serous, low-grade endometrioid, clear cell and muci...
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A new paradigm for the pathogenesis of ovarian cancer has recently been proposed which helps to explain persistent problems in describing the development and diverse morphology of these neoplasms. The paradigm incorporates recent advances in our understanding of the molecular pathogenesis of epithelial 'ovarian' cancer with new insights into the origin of these tumors. Correlated clinicopatholo...
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Background. Fibrothecomas are benign sex cord-stromal tumors which rarely originate outside of the ovary. To date, two such cases have been reported in the literature. We report the third case of an extraovarian fibrothecoma and the first presenting similarly to a metastatic epithelial ovarian cancer. Clinical History. We describe a 62-year-old woman with history, physical examination, and imag...
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Primary ovarian carcinoma is a heterogeneous group of diseases and each subtype is characterized by distinct clinical, histologic, and molecular features. Ovarian cancers can be broadly subdivided into Type I and Type II tumors. This classification is not a histologic one, but describes tumorigenic pathways based on clinically correlated molecular data. Type I tumors include low-grade serous, l...
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Ovarian cancer is the most lethal gynecologic malignancy. Efforts at early detection and new therapeutic approaches to reduce mortality have been largely unsuccessful, because the origin and pathogenesis of epithelial ovarian cancer are poorly understood. Despite numerous studies that have carefully scrutinized the ovaries for precursor lesions, none have been found. This has led to the proposa...
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ژورنال
عنوان ژورنال: Human Pathology
سال: 2011
ISSN: 0046-8177
DOI: 10.1016/j.humpath.2011.03.003